The Technology

empowered with bioluminescence

LucArray’s technology combines an extraordinarily sensitive light detector with very bright light-producing molecules from the deep ocean to perform up to a hundred different diagnostic tests on a small biological sample. LucArray’s unique architecture enables testing even of “dirty” samples such as whole blood, without the need for time-consuming sample preparation.

The ultimate in miniaturization, the LucArray System begins with a cartridge about the size of a USB thumb-drive and contains a sensitive, patented chip with 112 individual detectors that can be read simultaneously, yet is smaller than the head of a pencil eraser. A sample is placed into the cartridge’s port and the cartridge is docked with the LucArray Reader. Designed to utilize various detection methods if a disease biomarker is detected in a sample, light will be generated at a specific location on the array and quickly reported. The luciferase used to generate the light signal comes from a deep-sea copepod and produces a bright blue light estimated to be up to 1000 times brighter than firefly luciferase that is widely used in biological testing.
Magnification of the LucArray. The 112 detectors are visible as dark dots on the light-sensitive microchip.

The combination of an extremely sensitive detector and an extremely bright signal make for a unique biological detection system, the LucArray System. Despite its superlative signal strength and sensitivity, the detector cartridge is inexpensive enough to discard after use.

A smartphone platform offers a wide variety of connectivity options to send the test results where they can be immediately acted upon: from the ER to the physician, from the en-route ambulance to the ER, from the village nurse to the regional hospital, or from the battlefield to the command center.

Tests can be adapted for nucleic acid hybridization and ELISA-type immunodetection. LucArray is capable of detecting the presence of specific motifs of a given target and can be tailored for quantitation of protein and nucleic acid molecule counts to assess burden.